Appeal No. 2002-1575 Page 6 Application No. 08/945,901 147 (CCPA 1976). “If a prima facie case is made in the first instance, and if the applicant comes forward with reasonable rebuttal, whether buttressed by experiment, prior art references, or argument, the entire merits of the matter are to be reweighed.” In re Hedges, 783 F.2d 1038, 1039, 228 USPQ 685, 686 (Fed. Cir. 1986). On this record, the examiner makes no attempt to rebut appellants’ argument and evidence, demonstrating that “the stimulative effects on the proliferation of corneal keratocytes and effects on the strength of a wound closure site are not inherently the same.” Brief, pages 7-8. For the foregoing reasons, it is our opinion that the claimed invention is not obvious over Mita. CONCLUSION The rejection of claims 4, 5, 8-15, 21, and 24-30 under 35 U.S.C. § 102(b) as anticipated by or, in the alternative, under 35 U.S.C. 103 as obvious over Mita is reversed. REVERSED Donald E. Adams ) Administrative Patent Judge ) ) ) BOARD OF PATENT Demetra J. Mills ) Administrative Patent Judge ) APPEALS AND ) ) INTERFERENCES Lora M. Green ) Administrative Patent Judge ) DA/dymPage: Previous 1 2 3 4 5 6 7 NextLast modified: November 3, 2007