Ex Parte HIKIDA et al - Page 6


                Appeal No.   2002-1575                                                  Page 6                
                Application No.  08/945,901                                                                   
                147 (CCPA 1976).  “If a prima facie case is made in the first instance, and if the            
                applicant comes forward with reasonable rebuttal, whether buttressed by                       
                experiment, prior art references, or argument, the entire merits of the matter are            
                to be reweighed.”  In re Hedges, 783 F.2d 1038, 1039, 228 USPQ 685, 686                       
                (Fed. Cir. 1986).  On this record, the examiner makes no attempt to rebut                     
                appellants’ argument and evidence, demonstrating that “the stimulative effects                
                on the proliferation of corneal keratocytes and effects on the strength of a wound            
                closure site are not inherently the same.”  Brief, pages 7-8.                                 
                      For the foregoing reasons, it is our opinion that the claimed invention is              
                not obvious over Mita.                                                                        
                                               CONCLUSION                                                     
                      The rejection of claims 4, 5, 8-15, 21, and 24-30 under 35 U.S.C. § 102(b)              
                as anticipated by or, in the alternative, under 35 U.S.C. 103 as obvious over Mita            
                is reversed.                                                                                  
                                                 REVERSED                                                     

                                   Donald E. Adams                 )                                          
                                   Administrative Patent Judge     )                                          
                                                                   )                                          
                                                                   ) BOARD OF PATENT                          
                                   Demetra J. Mills               )                                          
                                   Administrative Patent Judge     )   APPEALS AND                            
                                                                   )                                          
                                                                   ) INTERFERENCES                            
                                   Lora M. Green                  )                                          
                                   Administrative Patent Judge     )                                          
                DA/dym                                                                                        








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