Appeal No. 2003-0480 Page 2
Application No. 08/090245
sensing means, and thereby forming an antibody-reactant
complex, catalytically converting said complexed reactant to
said product and releasing said product from said complex,
thereby regenerating said antibody or fragment; and
(b) collecting from the sensing means information relating to said
changes and thereby detecting physical or chemical changes in
the environment.
85. A method as recited in claim 83, wherein said catalytically active
antibody or fragment is contained in or on a cell, a component of a
cell, or a tissue.
86. A method for detecting physical or chemical changes in an
environment wherein said changes are the result of a chemical
reaction taking place therein in which at least one reactant is
converted to at least one product, which method comprises:
(a) contacting said reactant with a catalytic monoclonal antibody or
fragment thereof which is capable of catalyzing said chemical
reaction, whereby said chemical reaction occurs in said
environment, said catalytic monoclonal antibody or fragment
thereof being immobilized on a surface of, or on a surface
associated with, a transducer, and thereby forming an antibody-
reactant complex, catalytically converting said complexed
reactant to said product and releasing said product from said
complex, thereby regenerating said antibody or fragment;
(b) transducing the physical or chemical changes in the
environment as a result of said chemical reaction into
information related to said changes; and
(c) processing the information generated by the transducer in
response to the physical or chemical changes resulting from
said chemical reaction and thereby detecting physical or
chemical changes in the environment.
88. A method for detecting an analyte of interest in an environment
wherein the analyte is consumed or generated during the course of
a chemical reaction, which method comprises
(a) contacting said analyte of interest to bind a catalytic monoclonal
antibody or a fragment thereof immobilized on a surface, or on a
surface associated with sensing means, thereby forming an
antibody-analyte complex
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