Ex Parte BLACKBURN et al - Page 13


                Appeal No.  2003-0480                                                  Page 13                
                Application No.  08/090245                                                                    
                      For the foregoing, we affirm the rejection of claim 86 under 35 U.S.C.                  
                § 103 as being unpatentable over Schochetman in view of Schenck and                           
                Conover, further in view of appellants statements as to the state of the art at               
                pages 3-6 of the specification.  As set forth above, claim 87 falls together with             
                claim 86.                                                                                     
                Claim 88:                                                                                     
                      According to step (b) of claim 88, the sensing means detects the binding                
                of the analyte to the catalytic monoclonal antibody.  As appellants point out                 
                (Brief, page 15), “catalysis is utilized not as the basis of the signal generation, but       
                as a means to regenerate the antibody or antibody fragment on the surface after               
                the measurement is completed.”                                                                
                      We recognize the examiner’s theory (Answer, page 9), “[g]iven that one                  
                could make a catalytic antibody against an antigen of interest, which antibody                
                was not terribly efficient as a catalyst … one could measure the amount [of                   
                analyte] bound and then allow the sensor to regenerate over time.”  However, in               
                our opinion, while one could imagine this possibility after reading appellants’               
                specification, we find no suggestion in the combination of references provided by             
                the examiner to support such a theory.  In re Gordon, 733 F.2d 900, 902, 211                  
                USPQ 1125, 1127 (Fed. Cir. 1984).                                                             














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