Ex Parte BLACKBURN et al - Page 7


                Appeal No.  2003-0480                                                   Page 7                
                Application No.  08/090245                                                                    
                Conover detects analytes via detection of a product of an enzyme-catalyzed                    
                reaction.”                                                                                    
                      In conclusion, appellants argue (Brief, page 13), “the combination of                   
                Schochetman and Schenck would yield a device for measuring the rate of                        
                catalysis and not analyte concentration.”  We note, however, that claim 83 does               
                not require the measurement of analyte concentration.  Claim 83 requires only                 
                that the catalytically active antibody or fragment catalyze a chemical reaction               
                (e.g., a physical or chemical change in an environment) that is detected by the               
                sensing means.  In our opinion, measuring the rate of catalysis, as appellants                
                admit is taught by Schochetman and Schenck, is just such a physical or chemical               
                change in an environment as is required by claim 83.                                          
                      Accordingly, we affirm the rejection of claim 83 under 35 U.S.C. § 103 as               
                being unpatentable over Schochetman in view of Schenck and Conover, further                   
                in view of appellants statements as to the state of the art at pages 3-6 of the               
                specification.  As set forth above, claim 84 falls together with claim 83.                    
                Claim 85:                                                                                     
                      According to the examiner (id.), claim 85 “requires that the catalytic                  
                antibody be ‘contained in or on a cell, a component of a cell, or a tissue.’  A               
                component of a cell is literally any … molecular fragment or molecule found                   
                therein.  Thus immobilization on a cellulose acetate membrane, both cellulose                 
                and acetate are components of cells, would suffice to meet the required                       
                limitation.”                                                                                  








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