Interference No. 103,675
The efficacy of certain compounds prepared in the foregoing
examples was tested for in vitro cytotoxicity and for tumor inhibition
in Balb/c mice (see pages 33 through page 35, line 18). Specifically,
the compounds prepared in Examples 3, 4, 6, 8 and 9 were tested in
vitro and compared with the efficacy of taxol for cytotoxicity against
human colon carcinoma cells. Additionally, Balb/C mice were implanted
with lung carcinoma and then injected with either the compound of
Example 3 or Example 6 and the median survival time for said mice was
compared to the median survival time for control mice. Both tests
showed the compounds prepared in the Examples possessed tumor
inhibiting activity.
The application concluded with claims to the genus of
compounds having the formula I. Additionally, Chen et al. claimed:
various species within the broad genus of compounds; fluoro baccatins
III of the formula IV; pharmaceuticals comprising a compound from the
genus of compounds having the formula I and associated with one or
more carriers, excipients or diluents; and, a method for treating
mammalian tumors comprising administering to a mammal a tumor
sensitive amount of a compound within the genus of compounds defined
by formula I.
On August 2, 1992, the examiner issued a Notice of
Allowability of claims 1 through 18 and attached a Notice of
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