F 42. Par6 947 describes a process in which a material containing the volatile component is placed
in a container which is then sealed with a selective semipermeable membrane, microwaves
are applied to effect volatilization and the desired volatile components separated by passing
them through a semi-permeable membrane. P. Ex. 2001, col. 3 ), 11. 36-50.
F41. Par6 947 describes the use of asemipermeable membrane to separate the volatile components
from the contents of the container. P. Ex. 2001, col. 6.11. 21-23.
F 44. Par6 947 also describes the use of a sorbent to absorb and separate the volatile components
released by the application of microwaves. P. Ex. 2001, col. 4,11. 62-64; col. 8,11. 4-11.
F 45. The particular sorbent is said to be dependent upon the particular volatile material of interest.
P. Ex. 2001, col. 8,11. 22-25.
F 46. Par6 947 also describes placing samples into sealed headspace vials and applying microwave
energy. E.g., P. Ex. 2001, col. 7,11. 31-51; col. 8,11. 41-63.
F 47. Par6 947 says that the microwave power applied to a sample in a closed container "was kept
low to minimize the over pressurizing of the headspace vials and the potential for losses due
to leaks or the potential for explosion." P. Ex. 2001, col. 10, 11. 7-9; col. 12,11. 12-14.
F 48. Example 2 of Pard 947 is identical to Example 2 of Pard 426 reproduced above.
F 49. Par6 947 does not expressly describe intermittently applying vacuum or reduced pressure
during the exposure to microwaves.
F 50. Pard 947 does not expressly describe hydrodistilling the natural product by conveying the
natural product and water as an azeotropic mixture and separating the natural product from
the azeotrope.
3) The Ganzier Publication (Ganzler)
F 51. The Ganzler publication relates to a method of preparing samples for chromatography
employing microwave radiation. P. Ex. 2003, p. 299, Summary.
F 52. According to the publication, the samples to be studied are ground and mixed with an
appropriate solvent. P. Ex. 2003, p. 299, Summary.
F 53. The mixture was said to be placed in sealed vials and repeatedly subject to irradiation for
thirty seconds without allowing the mixture to boil and cooling to room temperature. P.Ex.
2003,p.301.
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