Ex Parte BAKER et al - Page 7




              Appeal No. 2003-1736                                                                                        
              Application No. 09/123,137                                                                                  
              types of enzymes.”  Reply Brief, page 4.                                                                    
                     In the present case, the examiner has failed to indicate the specific under-                         
              standing or principle within the knowledge of a skilled artisan, explicit or implicit, that                 
              would have motivated one with no knowledge of appellants' invention to make the                             
              combination in the manner claimed.   In re Rouffet, 149 F.3d 1350, 1357, 47 USPQ2d                          
              1453, 1457 (Fed. Cir. 1998).  In re Kotzab, 217 F.3d 1365, 1369-70, 55 USPQ2d 1313,                         
              1316 (Fed. Cir. 2000).                                                                                      
                     What is missing from the examiner’s analysis is a sufficient reason, suggestion                      
              or motivation to combine the cited references.  More particularly, the examiner has not                     
              indicated why one of ordinary skill in the art would have been motivated to select or                       
              include active oxygen inhibitors, such as SOD,  in the prior art hydrogels.  While it is                    
              clear from the record that both SOD and hydrogels were known in the art, we do not                          
              find the examiner has established with proper evidence, the motivation to incorporate                       
              an active oxygen inhibitor in a hydrogel.                                                                   
                     We do not agree with the examiner that the mention of the incorporation of                           
              enzymes in a hydrogel (WO 93/17669) would have suggested the incorporation of SOD                           
              in a hydrogel.   It is well settled that the fact that a claimed species or subgenus is                     
              encompassed by a prior art genus is not sufficient by itself to establish a prima facie                     
              case of obviousness. In re Baird, 16 F.3d 380, 382, 29 USPQ2d 1550, 1552 (Fed. Cir.                         
              1994) (“The fact that a claimed compound may be encompassed by a disclosed generic                          
              formula does not by itself render that compound obvious.”); In re Jones, 958 F.2d 347,                      

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