Appeal No. 2003-1736 Application No. 09/123,137 types of enzymes.” Reply Brief, page 4. In the present case, the examiner has failed to indicate the specific under- standing or principle within the knowledge of a skilled artisan, explicit or implicit, that would have motivated one with no knowledge of appellants' invention to make the combination in the manner claimed. In re Rouffet, 149 F.3d 1350, 1357, 47 USPQ2d 1453, 1457 (Fed. Cir. 1998). In re Kotzab, 217 F.3d 1365, 1369-70, 55 USPQ2d 1313, 1316 (Fed. Cir. 2000). What is missing from the examiner’s analysis is a sufficient reason, suggestion or motivation to combine the cited references. More particularly, the examiner has not indicated why one of ordinary skill in the art would have been motivated to select or include active oxygen inhibitors, such as SOD, in the prior art hydrogels. While it is clear from the record that both SOD and hydrogels were known in the art, we do not find the examiner has established with proper evidence, the motivation to incorporate an active oxygen inhibitor in a hydrogel. We do not agree with the examiner that the mention of the incorporation of enzymes in a hydrogel (WO 93/17669) would have suggested the incorporation of SOD in a hydrogel. It is well settled that the fact that a claimed species or subgenus is encompassed by a prior art genus is not sufficient by itself to establish a prima facie case of obviousness. In re Baird, 16 F.3d 380, 382, 29 USPQ2d 1550, 1552 (Fed. Cir. 1994) (“The fact that a claimed compound may be encompassed by a disclosed generic formula does not by itself render that compound obvious.”); In re Jones, 958 F.2d 347, 7Page: Previous 1 2 3 4 5 6 7 8 9 10 11 NextLast modified: November 3, 2007