Ex Parte BAKER et al - Page 9




              Appeal No. 2003-1736                                                                                        
              Application No. 09/123,137                                                                                  
              prior art references.”  Ecolochem, Inc. v. Southern California Edison Co., 227 F.3d                         
              1361, 1371, 56 USPQ2d 1065, 1073 (Fed. Cir. 2000).                                                          
                     In this situation, the examiner's rejection fails to show that one of ordinary skill in              
              the art would have been motivated to incorporate an active oxygen species in a                              
              hydrogel, as claimed.  In addition, the prior art noted in the specification discloses that                 
              the efficacy of SOD use for the treatment of ischemic/reperfusion events and pelvic                         
              adhesions has been limited by its rapid elimination from the blood stream.                                  
              Specification, page 4.  The examiner has not provided sufficient evidence to indicate                       
              why one of ordinary skill in the art would have been motivated to incorporate an active                     
              oxygen inhibitor which is known to be rapidly eliminated from the blood stream into a                       
              hydrogel, as claimed.   Nor has the examiner provided evidence as to why one of                             
              ordinary skill in the art in view of the prior art disclosure of systemic administration of                 
              oxygen inhibitors such as SOD, would have been motivated to apply such compositions                         
              topically or would have had an expectation of success that the composition would                            
              continue to deliver the active oxygen inhibitor, normally rapidly eliminated from the                       
              blood stream, at a site for days to weeks.                                                                  
                     We do not reach appellants' argument or evidence of unexpected results, as we                        
              do not find the examiner has established a prima facie case of obviousness.   The                           
              rejection of the claims for obviousness is reversed.                                                        
                     No time period for taking any subsequent action in connection with this appeal                       
              may be extended under 37 CFR § 1.136(a).                                                                    

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