Interference 103,781
December 12, 1986, the fact is that Shaw dealt with the stability
of mRNAs of certain lymphokines, cytokines, and protooncogenes in
animals (AX 121L, Shaw’s Summary). We find little, if any,
difference in the certainty with which Adang explained the
evidence of premature termination of transcription and
inefficient expression of Bt DNA sequences encoding insecticidal
protein in plants and planned future experimentation before and
after Drs. Adang and Murray were “impressed” and “excited” by
Shaw’s disclosure.
Adang alleges (AB 50, Facts 123-125), and the evidence
appears to show, that Dr. Adang searched for and found ATTTA
sequences in Bt genes prior to December 12, 1986 (AR 6878-6879,
para. 9; AX 106I; AR 0371-0374; AX 34C). Nevertheless, the same
evidence shows that Adang’s efforts to identify any and all
possible RNA destabilizing sequences continued through December
of 1987. Dr Adang declared (AR 6878-6879, para 9; citations
omitted (see AX 106I for computer searches from March 1986 though
December 1987)):
From March of 1986 through December of 1987, I
performed sequence analyses of Bt genes to identify RNA
destabilizing sequences which would need to be reduced
and/or eliminated to enable increased Bt gene expression.
In addition, I continued sequence analysis and comparisons
of the Bt genes. Other sequence analyses to locate RNA
destabilizing sequences in Bt genes were performed by other
Agrigenetics scientists. These efforts are reflected in the
following computer searches: . . . .
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