Interference 103,781
insecticidal protein in plants. Within the period extending from
December 12, 1986, through the summer of 1988, Drs. Adang and
Murray performed a series of experiments, tests, computer
searches, and analyzes to determine with as reasonable degree of
certainty which of the suspect causes, i.e., potential solutions,
was most likely to bring success. Adang has not directed our
attention to any evidence of record, and we have not found any
evidence of record, that indicates that before December 12, 1986,
Dr. Adang or Dr. Murray had selected ATTTA as a likely cause -
let alone as the probable cause - of the RNA instability problem.
Rather, it was merely one of many potential causes. It was only
the collective gathering of evidence by Drs. Adang and Murray
throughout 1987 and 1988 that enabled them to identify with
confidence a cause of the problems they had experienced
expressing Bt genes in plants and a way and means most likely to
eliminate their problems. Compare the earlier potential solution
to the later confidence with which Dr. Adang identified ATTTA as
a mRNA destabilizing sequence and proposed its elimination from
Bt genes in 1988:
The Btt sequence was scanned for sequences such as AATAAA
and ATTTA that should be eliminated. [(AR 0376);]
Q. On or about April 12th of 1988 was it your view
that the ATTTA sequence should be eliminated from the native
Bt gene as stated on this page?
. . . . .
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