Appeal No. 2003-2147 Application No. 09/392,243 In the present case, the examiner has failed to provide sufficient evidence that one of ordinary skill in the art would readily substitute one preservative for another, in view of evidence present in the record that preservatives of the prior art in fact function differently than the claimed preservative. Moreover, the evidence of record reasonably appears to reasonably show that specific preservatives are for required for specific applications and thus one of ordinary skill in the art would not readily substitute one preservative for another. We particularly note appellants' Exhibit D, Tables 11-1 and 11-3, provides evidence that preservatives have distinct applications. From the examiner's perspective Table 11-1 of Exhibit D provides that certain preservative have multiple applications (Answer, page 7), but th examiner does not acknowledge the reference's teaching that other preservatives do not have general application or provide evidence that the specific claimed preservatives are known in the art to have general application, or particular application to the preservation of mucosa tissue. In view of the above, we reverse the rejection of the claims over Van Gorp in view of Balslev and Oles. Other Issue Upon return of the application to the examiner, it is recommended that the examiner carefully review the disclosure of Hiles, U.S. Patent No. 6,666,892 (attached) and determine its relevance under 35 U.S.C. § 102(e) or 103(c), if any, to the claimed subject matter. In particular, Hiles would appear to have a filing date, May 27, 1999, 9Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 NextLast modified: November 3, 2007