Ex Parte LEE et al - Page 9




             Appeal No. 2003-2147                                                                              
             Application No. 09/392,243                                                                        
                   In the present case, the examiner has failed to provide sufficient evidence that            
             one of ordinary skill in the art would readily substitute one preservative for another, in        
             view of evidence present in the record that preservatives of the prior art in fact function       
             differently than the claimed preservative.  Moreover, the evidence of record reasonably           
             appears to reasonably show that specific preservatives are for required for specific              
             applications and thus one of ordinary skill in the art would not readily substitute one           
             preservative for another.  We particularly note appellants' Exhibit D, Tables 11-1 and            
             11-3, provides evidence that preservatives have distinct applications.  From the                  
             examiner's perspective Table 11-1 of Exhibit D provides that certain preservative have            
             multiple applications (Answer, page 7), but th examiner does not acknowledge the                  
             reference's teaching that other preservatives do not have general application or provide          
             evidence that the specific claimed preservatives are known in the art to have general             
             application, or particular application to the preservation of mucosa tissue.                      
                   In view of the above, we reverse the rejection of the claims over Van Gorp in               
             view of Balslev and Oles.                                                                         


             Other Issue                                                                                       
                   Upon return of the application to the examiner, it is recommended that the                  
             examiner carefully review the disclosure of Hiles, U.S. Patent No. 6,666,892 (attached)           
             and determine its relevance under 35 U.S.C. § 102(e) or 103(c), if any, to the claimed            
             subject matter.  In particular, Hiles would appear to have a filing date, May 27, 1999,           

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