Ex Parte Liu et al - Page 5


               Appeal No. 2005-0295                                                                                                  
               Application 10/151,586                                                                                                

                       Abdel-Malik also discloses that zein may be used alone or in combination with other                           
               proteins (e.g., col. 11, ll. 58-63).  The reference teaches a non-limiting grouping of “organic                       
               plasticizers” as well as a preferred grouping thereof, wherein the listing includes certain types of                  
               organic compounds that include a number of specific plasticizers from Table 1 as well as                              
               additional specific plasticizers, but without reference to any specific protein, and indeed, one of                   
               ordinary skill in this art would have inferred from this disclosure that this listing of plasticizers is              
               generic and not based on a particular protein, of which the reference discloses a number of                           
               different types (col. 4, ll. 14-17, col. 11, ll. 58-67, and col. 12, ll. 8-27).  Another grouping of                  
               typical plasticizers includes ethanol, propylene glycol, ethylene glycol, acetic acid and lactic acid                 
               (col. 12, ll. 37-45).  A disclosed group of blends is based on zein and different plasticizers                        
               including water (col. 12, ll. 46-51).  Abdel-Malik further illustrates the procedure for identifying                  
               plasticizers for zein in Example 1, Tables 5 and 6, namely ethanol and propylene glycol (col. 20,                     
               l. 17, to col. 21, l. 4), and for forming plasticizer proteinaceous materials from zein with glycerol                 
               and propylene glycol, with and without water, and with propylene glycol alone in Example 2,                           
               Tables 9, 10a-c, 11, 12, 23 and 33 (cols. 21-24, 30 and 33).  The reference further illustrates gum                   
               preparation with plasticized proteinaceous material, including chewing gums, with zein                                
               plasticized with glycerol, propylene glycol, and other ingredients in Example 3, Subexamples                          
               A3, B1, B5, B7, B9, B10 (cols. 35, 36 and 38-40).                                                                     
                       With respect to the grounds of rejection under §§ 102(b) and 103(a), the examiner finds                       
               that Abdel-Malik discloses a method of preparing a gum base of zein and a plasticizer as                              
               claimed, wherein a number of plasticizers listed in col. 12 fall within the claimed ranges for the                    
               electron acceptor to total carbon atoms ratio (EA/C) and electron donor to total carbon atoms                         
               ratio (ED/C), and are the same plasticizers disclosed by appellants in specification Table 1 (page                    
               12), including lactic acid, propylene glycol, ethyl lactate and butyl lactate, thus inherently                        
               satisfying the EA/C and the ED/C requirements of the claims (answer, pages 2-3).  The examiner                        
               further determines that finding the optimum EA/C and ED/C is a matter of routine                                      
               experimentation by one of ordinary skill in the art (id., page 3).                                                    
                       Appellants submit that Abdel-Malik does not teach selecting a plasticizer based on EA/C                       
               and ED/C (brief, page 11).  Appellants point out that the claimed ratios predict the amphiphilic                      
               properties of the plasticizer, pointing to page 7, ll. 6-11, of the specification, that is, sufficient to             

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