Ex Parte Liu et al - Page 10


               Appeal No. 2005-0295                                                                                                  
               Application 10/151,586                                                                                                

               disperse forces, polar forces and hydrogen bonding forces of both components, can be stated in                        
               terms of the EA/C and ED/C requirements of the plasticizer as in appealed method claim 1.                             
               However, it is well known to one skilled in this art that electron acceptors and donors affect the                    
               solubility of a carbon compound, and indeed, in this respect, appellants disclose the following:                      
                    A plasticizer varies the firmness of gum base by interposing itself between the                                  
                    macromolecular chains of a target compound. This is best accomplished when the                                   
                    attractive forces between the compounds of both components are similar. If the                                   
                    attractive forces are sufficiently dissimilar, immiscibility will result. Attraction forces                      
                    between molecules typically include dispersion force, polar forces, hydrogen bonding                             
                    forces and ionic forces. It is well known that ionic forces and hydrogen-bonding                                 
                    typically play important roles in protein dissolution in aqueous solution. In non-                               
                    aqueous media, the hydrogen-bonding tends to become the major driving force to                                   
                    form miscible blends between zein and plasticizers. Plasticizers are required to                                 
                    possess sufficient electron donors and electron acceptors in their molecular structure                           
                    in order to form effective hydrogen bonding with zein macromolecules. In this regard,                            
                    due to the amphiphilic nature of zein, the most effective plasticizers for zein are those                        
                    that possess a balance of hydrophobic and hydrophilic portions in their molecular                                
                    structures similar to zein. [Specification, page 6, l. 30, to page 7, l. 11.]                                    
                       We note that this disclosure is specific to zein and method claim 1 is not.                                   
                       The issue raised on this record, as correctly suggested by the examiner and appellants, is                    
               whether, prima facie, Abdel-Malik discloses a method embodiment which can reasonably be                               
               inferred to necessarily and inherently include the selection of a carbon compound plasticizer for                     
               a corn protein on the basis of the EA/C and ED/C of the carbon compound plasticizer, even                             
               though Abdel-Malik is silent in this respect, and thus is a method that is identical to the claimed                   
               method;  and if so, whether appellants have provided effective argument or evidence that                              
               patentably distinguishes the claimed method encompassed by claim 1 over such disclosure of                            
               Abdel-Malik.  See, e.g., Spada, 911 F.2d at 708-09, 15 USPQ2d at 1657-58 (“it was reasonable                          
               for the PTO to infer that the polymerization by both Smith and Spada of identical monomers,                           
               employing the same or similar polymerization techniques, would produce polymers having the                            
               identical composition,” shifting the burden to appellant to show that the products are not                            
               identical); In re Best, 562 F.2d 1252, 1254-55, 195 USPQ 430, 432-33 (CCPA 1977) (the                                 
               examiner reasonably concluded on evidence in the reference that process disclosed therein                             
               necessarily cooled the product which included the finding that the gas stream inherently removed                      
               generated ammonia even though the reference was silent on the matter, shifting the burden to                          


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