Ex Parte Pugliese - Page 23



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

               Moreover, genistein is not representative of all the                    
          alternative isoflavones of Pugliese’s claims.  Note that genistein           
          is four times the PDE inhibitor that its alternative daidzein is             
          (Kuppusamy, p. 1309, Table 2).  Accordingly, Pugliese showing is not         
          commensurate in scope with the scope of the compositions and methods         
          claimed.  “[O]bjective evidence of nonobviousness must be                    
          commensurate in scope with the claims.”  In re Kulling, 897 F.2d             
          1147, 1149, 14 USPQ2d 1056, 1058 (Fed. Cir. 1990).                           
               We have considered all the evidence and arguments favoring              
          patentability and all the evidence and arguments to the contrary. In         
          our view, the examiner’s case for unpatentability of the claimed             
          subject matter under 35 U.S.C. § 103 is supported by the greater             
          weight of all the evidence.  Accordingly, we affirm the examiner’s           
          final rejection of Claims 1-7 and 9-11 of Application 09/989,019             
          under 35 U.S.C. § 103 in view of the combined teachings of Soudant,          
          Koulbanis, Majeed, Sekiya, De Simone, Lotte, Kuppusamy, and Gennaro.         
          AFFIRMED.                                                                    
                     New Ground of Rejection Under 37 CFR § 41.50(b)                   
               THIS IS A NEW GROUND OF REJECTION.  Method Claim 8 of                   
          Application 09/989,019 is hereby rejected anew under 35 U.S.C.               
          § 103 in view of the combined teachings of Soudant, Koulbanis,               
          Majeed, Sekiya, De Simone, Lotte, Kuppusamy, and Gennaro.  In the            
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