Appeal No. 2005-0545
Application No. 09/989,019
in Exhibit A, titled “Density Measurements of Ultrasound
Scans”;
6. Such measurements were made at 1 (blue bar),
28 (purple bar), and 56 (yellow bar) day intervals starting
from initial topical application of Formula No. 3, assess
average epidermis density, average papillary dermis density,
and average reticular dermis density, respectively;
7. Papillary dermis density is an indicator of
connective tissue cell replacement, while reticular dermis
density is an indicator of reduction in fat cell size and/or
number;
8. As a medically licensed physician and clinician,
it is my professional opinion that the exemplary isoflavone,
genistein, shows a measurable increase (c. 5 units) in
epidermis density at 28 days, followed by a slight dip at
day 56; a progressive increase in papillary dermis density
from c. 27 units at day one to c. 48 units at day 56; and,
a progressive increase in reticular dermis density from
c. 35 units at day 1 to c. 66 units at day 56;
9. Five women with clinically determined moderate
cellulite were treated with an emulsion like Formula #3, but
having active components, save genistein being omitted, and
the emulsifiers and emollients being retained, with twice
daily applications to both thighs; the degree of cellulite
was determined by measuring visual ratio of connective
tissue to fat infiltration into connective tissue;
10. Based on ultrasound measurements, made at both
four and eight weeks, the amount of fatty tissue decreased,
while the amount of connective tissue increased by about 8%
at four weeks, and by 19% at eight weeks, respectively
(Exs. B & C).
20
Page: Previous 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Next
Last modified: November 3, 2007