Ex Parte Pugliese - Page 13



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

          as a whole, implicitly would have suggested Pugliese’s claimed               
          multicomponent composition and method for its use to persons having          
          ordinary skill in the art with reasonable expectation of success.            
          See In re O’Farrell, 853 F.2d 894, 903, 7 USPQ2d 1673, 1681                  
          (Fed. Cir. 1988)(for obviousness under § 103, all that is required           
          is a reasonable expectation of success).  Moreover, the examiner             
          correctly states that it is not necessary for our holding of                 
          obviousness that persons having ordinary skill in the art would have         
          been led to make and use the compositions and methods Pugliese               
          claims for the reasons Pugliese discloses.  See In re Dillon,                
          919 F.2d 688, 693, 16 USPQ2d 1897, 1901 (Fed. Cir. 1990)(en banc),           
          cert. denied, 500 U.S. 904 (1991):                                           
               Each situation must be considered on its own facts, but                 
               it is not necessary in order to establish a prima facie                 
               case of obviousness that . . . the claimed compound or                  
               composition will have the same or a similar utility.                    
               On consideration of the prior art as a whole, we conclude that          
          persons having ordinary skill in the art reasonably would have been          
          led to make and use compositions comprising at least one of                  
          components selected from (a) quercetin and fisetin, (b) genistein            
          and daidzein, (c) carnitine, (d) theophylline, caffeine and                  
          theobromine, and (e) plant extract of Coleus Forskohli, with                 
          solubilizing and/or emulsifying agents suitable for oral or topical          

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