Ex Parte Pugliese - Page 8



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

          accumulation of fat is an important component of the condition               
          called “cellulite” (Spec., p. 1, l. 12-17; emphasis added):                  
                    [A] condition of the buttocks and upper thighs                     
               characterized by an unattractive, undulating, irregular                 
               skin surface.  The condition has been thought by previous               
               investigators to originate from abnormal fatty deposits                 
               that collected under the skin.  Many attempts have been                 
               made to define cellulite but no adequate explanation has                
               been forthcoming.  While fat is not the major etiological               
               factor in cellulite, it is an important component of the                
               condition.                                                              
          Pugliese teaches that “[t]he use agents that are capable of                  
          lipolytic stimulation, such as the xanthine derivatives, caffeine            
          and theophylline, has shown some efficacy in published clinical              
          trials” (Spec., p. 3, l. 10-12).  While Pugliese suggests that the           
          primary cause of cellulite is estrogen (Spec., p. 3, l. 12-13),              
          nevertheless, “[c]ellulite is a condition seen only in women and is          
          characterized by the formation of fatty deposits . . . in the thighs         
          and the buttocks” (Spec., p. 4, l. 8-9).  Thus, while Pugliese’s             
          specification does not explicitly define the term “cellulitis” in            
          Claim 8, it appears from the art of record that “[c]ellulitis is             
          [’an inflammatory condition of cellular or connective tissues’               
          (AB12, footnote)] formed by local accumulation of fat” (Soudant,             
          col. 1, l. 66-68); i.e., a medical condition relating to local               
          accumulation of fat.                                                         

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