Ex Parte Pugliese - Page 4



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

               Taber’s Medical Dictionary 1981 Ed. Pg. 37.                             
                                        . . . . .                                      
                    Lastly, the enclosed Rule 132 Declaration establishes              
               that representative flavones are capable of inhibiting the              
               undesirable destructive effects of estrogen on connective               
               tissue and thus provide a positive effect on treating                   
               cellulite, not cellulitis.                                              
               Contrary to appellant’s view, yet consistent with statements of         
          the examiner, we find that Koulbanis and Soudant both describe               
          treatments for cellulitis.  See Koulbanis, Abstract; col. 1,                 
          l. 7-9, 50, 56-57, 60, and 67-68; col. 2, l. 7-9; col. 3, l. 9-11;           
          col. 4, l. 40, 54, 56, and 68; col. 5, l. 5, 54; and col. 6, l. 15           
          and 56.  See Soudant, col. 1, l. 61-68; col. 2, l. 3-4; and col. 4,          
          l. 58-64.  Soudant defines “cellulitis” as “that swelling of the             
          subcutaneous connective tissue . . . [which] gives the skin an               
          ‘upholstered’ appearance” (Soudant, col. 1, l. 64-66).  The                  
          condition defined as cellulitis is formed by local accumulation of           
          fat and water trapped in a matrix of more or less fluid-tight                
          compartments” (Soudant, col. 1, l. 66-68).  Soudant would have               
          taught persons having ordinary skill in the art that the condition           
          known as cellulitis not only forms from, and is associated with,             
          “local accumulation of fat” (Soudant, col. 1, l. 66-68), but also            
          that one may treat associated cellulitis by treatments which combat          
          local accumulation of fat.  Soudant states (Soudant, col. 4,                 
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