Appeal No. 2005-0545 Application No. 09/989,019 accumulation of fat when administered orally or topically with suitable solubilizing and emulsifying agents for the elected form of delivery. See, for example, Soudant, col. 3, l. 49, col. 4, 64, and Examples 1-8; Koulbanis, col. 2, l. 67, to col. 3, l. 54, and Examples III-VI; Majeed, col. 4, l. 47-49; and Sekiya, col. 2, l. 35-58. There are more explicit reasons why persons having ordinary skill in the art would have combined agents thought to be active for promoting fat degradation and/or lean body mass, controlling digestion and absorption of lipids, increasing lipolysis, inhibiting phosphodiesterase activity, promoting slimming, treating obesity and regenerating tissue. First, certain of the cited prior art references expressly state that persons having ordinary skill in the art should combine active agents for a variety of reasons. Soudant teaches persons having ordinary skill in the art to combine lipolytic agents selected from a group including “growth factors . . . xanthines . . . [and] carnitine . . .” (Soudant, col. 2, l. 27-42). Soudant explains that certain slimming agents, for example, the phosphodiesterase-inhibiting xanthine, caffeine, cannot be used in high concentration (Soudant, col. 2, l. 15-24; emphasis added): 15Page: Previous 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NextLast modified: November 3, 2007