Appeal No. 2005-0545
Application No. 09/989,019
these compositions may stimulate the activity of the
cytochrome oxidases. In other words, these compositions
may stimulate cellular respiration and oxidative metabolism.
Lotte teaches that “flavoids can be used alone or different
kinds of them can be mixed together” (Lotte, p. 9, first full
sentence). Kuppusamy teaches that “[m]any drugs used in the
treatment of various clinical disorders have been shown to exert a
synergistic increase in lipolysis . . .” (Kuppusamy, p. 1313,
col. 2, second para.). Poor solubility and resultant low
concentrations may limit the lipolytic activity of a single active
agent. Thus, higher total concentrations of active agents may be
able to induce lipolysis not achievable using a single active agent.
Id. Kuppusamy reports that the flavoids fisetin and quercetin,
“potent PDE inhibitors that exerted a competitive mode of
inhibition, showed a wide range of effects on lipolysis” (Kuppusamy,
p. 1314, col. 1, first full para.).
Majeed teaches that it was “well known in the literature that
forskohlin is related to lipolysis in isolated fat cells . . .
(Majeed, col. 2, l. 19-20; emphasis added). Forskohlin is reported
to be useful for the promotion of lean body mass (Majeed, col. 2,
l. 34-35) and may be use in combination with other nutritional
supplements (Majeed, col. 2, l. 61-63). Sekiya proposes the use of
isoflavones such as daidzein and genistein to promote lipolysis
17
Page: Previous 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Next
Last modified: November 3, 2007