Appeal No. 2005-0102 Page 2
Application No. 09/840,787
the amino acid sequence shown in the specification’s SEQ ID NO:19. See page 18.
The specification discloses that “HRM-19 is 351 amino acids in length and has . . . one
potential mitochondrial carrier motif, P31LDVVKVRL. HRM-19 has sequence homology
with C. elegans C16C10 (g577542) and is found in cDNA libraries associated with cell
proliferation, cancer and immune response.” Id.
The specification does not disclose any specific activity or function possessed by
either HRM-19 or proteins having mitochondrial carrier motifs. Regarding “human
regulatory molecules” generally, the specification discloses that
[r]egulatory protein molecules function to control gene expression. These
molecules turn individual or groups of genes on and off in response to
various inductive mechanisms of the cell or organism; act as transcription
factors by determining whether or not transcription is initiated, enhanced,
or repressed; and splice transcripts as dictated in a particular cell or
tissue.
Page 1.
The specification discloses that HRMs are useful in therapy, particularly for
cancers:
In one embodiment, where HRM is an inhibitor, HRM . . . may be
administered to a subject to treat a cancer such as adenocarcinoma,
leukemia, lymphoma, melanoma, myeloma, sarcoma, and terato-
carcinoma. Such cancers include, but are not limited to, cancers of the
adrenal gland, bladder, bone, bone marrow, brain, breast, cervix, gall
bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle,
ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin,
spleen, testis, thymus, thyroid, and uterus.
. . .
In a further embodiment where HRM is promoting cell proliferation,
antagonists which decrease the expression or activity of HRM may be
administered to treat a cancer such as adenocarcinoma, leukemia,
lymphoma, melanoma, myeloma, sarcoma, and teratocarcinoma. Such
cancers include, but are not limited to, cancers of the adrenal gland,
bladder, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia,
gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas,
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