Ex Parte Wolf - Page 7


                Appeal No. 2006-2467                                                  Page 7                 
                Application No. 10/157,644                                                                   

                      fructose snack since it may cause hyperglycemia.  Therefore, the                       
                      time frame in which the composition is administered is a                               
                      manipulatable parameter that is defined by the patient’s condition,                    
                      i.e. the blood sugar profile.                                                          
                Id. at 4-5.                                                                                  
                      Again appellants argue that “[n]one of the references disclose the                     
                administration of fructose from 10-90 minutes before a meal or snack.”  Appeal               
                Brief, page 7.  We agree, and the rejection is reversed.                                     
                      Moore looks at plasma glucose concentrations after administration of                   
                glucose or glucose supplemented with fructose, wherein blood samples were                    
                obtained twice before and every 15 minutes after administration, for a period of             
                two hours.  Thus, there is no discussion in either Anderson or Moore of when the             
                fructose supplementation was given to the subjects relative to a meal or snack.              
                      Lundstrom merely teaches an afternoon snack, given between lunch and                   
                dinner, of a piece of fruit.  See id. at 26.  There is no discussion of the timing of        
                lunch, the afternoon snack, and dinner.  Thus, again, there is no suggestion in              
                the Lundstrom reference, or in the combination, that a fructose supplement                   
                should be administered 10 to 90 minutes before a meal.                                       
                                              OTHER ISSUES                                                   
                      The examiner should consider the patentability of the claims in view of the            
                Van de Ven5 reference, the abstract of which accompanies this opinion.  In that              



                                                                                                             
                5 Van de Ven et al., “Effects of liquid preloads with different fructose/fibre concentrations on
                subsequent food intake and ratings of hunger in women,” Appetite, Vol. 23, No. 2, pp. 139-46 
                (1994) (abstract only).                                                                      





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