Ex Parte Bianchi et al - Page 9


            Appeal No. 2006-2546                                                          Page 9              
            Application No. 10/425,177                                                                        

            however, the examiner should consider whether the prior art as a whole would have                 
            suggested a composition meeting the limitations of the instant claims.  For example,              
            Hoeg3 teaches compositions that, like those of Krezanoski, gel rapidly under                      
            physiological conditions.  See, e.g., Hoeg at column 9, line 59 to column 10, line 8.             
            Unlike Krezanoski, Hoeg expressly suggests including detectable agents in the                     
            disclosed compositions.  See, e.g., column 15, lines 17-22.  See also Example X                   
            (column 19), in which a fluorescein-containing composition was administered to rabbit             
            eyes and “monitored using a slit lamp technique”:  “an incremental increase in                    
            fluorescence” was detected.                                                                       
                   On return of this case, the examiner should consider whether Hoeg or other prior           
            art would have suggested to those of ordinary skill in the art the composition defined by         
            any of the instant claims.                                                                        

















                                                                                                             
            3 Hoeg et al., U.S. Patent 5,441,732, issued August 15, 1995.                                     





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