Appeal No. 2006-0647
Application No. 10/069,561
stimulation of the agglutination reaction of fibrin monomer which is formed
from fibrinogen by the action of [ ] thrombin present in the . . . fiber[,] and
as a result of the stabilization of the agglutinates through a cross-linking
reaction of [ ] coagulation factor XIII” (Specification 3: 15-26). The fiber
also “promotes the adhesion and agglutination of [ ] platelets to the trauma
locus due to the rapid dissolving thereof on contact with [ ] blood or body
fluids present in the trauma site” (id. at 3: 33-36).
Claims 34 and 53 are representative of the subject matter on appeal
and read as follows:
34. A soluble trauma-healing hemostatic cellulose fiber, comprising
a natural or regenerated cellulose fiber that has been partially
carboxymethylated to an extent such that degree of substitution of the
hydroxyl groups in the glucose units constituting the cellulose
molecule is 0.5 - less than 1.0,
wherein three types of coagulation proteins being fibrinogen,
thrombin and coagulation factor XIII are applied or chemically
bonded to said fiber followed by drying,
such that said fiber possesses activity for accelerating a
coagulation reaction of fibrin monomers converted from fibrinogen
with thrombin and possesses activity for stabilizing agglutinates by
cross-linking reaction with the coagulation factor XIII.
53. A method of producing a soluble trauma-healing hemostatic
cellulose fiber, comprising the steps of:
treating a natural or regenerated cellulose fiber with an aqueous
sodium hydroxide solution,
reacting the thus-treated fiber with a monochloro acetic acid
solution for carboxymethylation to an extent such that degree of
substitution of hydroxyl groups of the glucose units constituting the
cellulose molecule (etherification degree) is 0.5 to less than 1.0,
subsequently refining the fiber and then imparting or chemical
bonding three coagulation proteins which are fibrinogen, thrombin
and coagulation factor XIII, to the refined cellulose fiber, and
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