Ex Parte Tsai et al - Page 12


                 Appeal No.  2007-0056                                                         Page 12                   
                 Application No.  09/906,511                                                                             
                 was made to incorporate time measurements as taught by Chandler into the                                
                 method taught by the combination of Kosako, ‘221, and ‘714.                                             
                        In response, appellants assert that Chandler teaches away from its                               
                 combination with Kosako, ‘211 and ‘978 because Chandler teaches the use of a                            
                 different instrument, specifically a flow cytometer, to measure particle size                           
                 distribution.  Brief, page 8.  We are not persuaded by this argument.  In our                           
                 opinion, that Chandler uses a flow cytometer rather than PIDS to measure                                
                 particle size distribution does not address the basis of the rejection – specifically,                  
                 that the measurement of particle size distribution as a function of time would                          
                 have been prima facie obvious in view of the combination of references relied                           
                 upon.  A flow cytometer is simply another instrument to measure particle size                           
                 distribution.  In our opinion, on this record, the recognition in the art of yet                        
                 another instrument to measure particle size distribution, without more, does not                        
                 lead to a conclusion that Chandler teaches away from its combination with                               
                 Kosako, ‘211, and ‘978.                                                                                 
                        As discussed above the combination of Kosako, ‘211, and ‘978 render the                          
                 invention of claim 1 prima facie obvious to a person of ordinary skill in the art at                    
                 the time the invention was made.  Regarding claim 3, which depends from                                 
                 claim 1, the examiner finds that Chandler teaches the measurement of particle                           
                 size distribution as a function of time as required by appellants’ claim 3.  Beyond                     
                 establishing that Chandler uses a different instrument to measure particle size                         
                 distribution, appellants’ have not provided any evidence or argument as to why it                       
                 would not have been prima facie obvious to modify the method taught by the                              






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