Ex Parte Tsai et al - Page 7


                 Appeal No.  2007-0056                                                          Page 7                   
                 Application No.  09/906,511                                                                             
                 method provided high resolution measurement of sub-micrometer and                                       
                 micrometer particle distribution.”  Id.  Accordingly, the examiner concludes that a                     
                 person of ordinary skill in the art “would have been motivated to employ PIDS                           
                 particles analysis to obtain the more sensitive particle discrimination/                                
                 measurement of smaller sized particle aggregates therein generating much more                           
                 accurate data for further evaluation of the analyte.”  Id.                                              
                        Appellants disagree with the examiner’s reasoning, asserting instead that                        
                        [s]ince the ‘714 patent requires measuring and subtracting size                                  
                        distribution of spurious particles while the PIDS technology does                                
                        not, the replacement of the 3-step measurement of size distribution                              
                        disclosed in the ‘714 patent with the PIDS technology would                                      
                        change the principle of operation of the method disclosed in the                                 
                        ‘714 patent.  Thus, the teachings of the cited references are not                                
                        sufficient to render the claimed invention prima facie obvious.                                  
                 Brief, page 6.  We disagree.  This is not a situation where the combined                                
                 references require a substantial reconstruction and redesign of Kosako’s                                
                 elements, or a change in the basic principle upon which Kosako’s method is                              
                 based.  Cf. In re Ratti, 270 F.2d 810, 813, 123 USPQ 349, 352 (CCPA 1959).  To                          
                 the contrary, the combination simply motivates a person of ordinary skill in the art                    
                 to replace one particle analysis technique with another “improved” particle                             
                 analysis technique.  While Kosako exemplifies one particle analysis technique,                          
                 the patent is not locked into one specific technique.  Instead, Kosako directs a                        
                 person of ordinary skill in the art to use “any suitable hardware, software, or                         
                 combination thereof.”  Kosako, column 3, lines 42-48.                                                   
                        According to appellants (Brief, page 5), the PIDS technique taught by ‘211                       
                 and ‘978 “does not involve measuring size distribution of spurious particles at all.                    






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