Appeal No. 2007-0057
Application No. 10/174,586
oxygen species may play a role in many important biological
processes. The transcription factors, NF-kappa B and AP-1, are
regulated by redox state and are known to affect the expression
of a large variety of genes thought to be involved in the
pathogenesis of AIDS, cancer, atherosclerosis and diabetic
complications. Such proteins may also play a role in cellular
antioxidant defense, and in pathological conditions involving
oxidative stress such as stroke and inflammation in addition to
having a role in apoptosis. Therefore, thioredoxins, and
proteins having homology thereto, are of interest to the
scientific and medical communities.
We herein describe the identification and characterization of
novel polypeptides having homology to thioredoxin, designated
herein as PRO270 polypeptides.
Page 25.
DISCUSSION
1. CLAIMS
Claims 25-32 and 35-37 are pending and on appeal. The claims have
not been argued separately; therefore, the claims subject to each rejection
stand or fall together. 37 CFR § 41.37(c)(1)(vii). Claims 25 and 30 are
representative and read as follows:
25. An isolated polypeptide having at least 80% amino acid sequence
identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO: 32;
(b) the amino acid sequence of the polypeptide of SEQ ID NO: 32,
lacking its associated signal peptide; or
(c) the amino acid sequence of the polypeptide encoded by the full-
length coding sequence of the cDNA deposited under ATCC accession
number 209392,
wherein said polypeptide has thioredoxin protein activity.
3
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