Ex Parte Arbiser - Page 12

                 Appeal No. 2007-0091                                                                                 
                 Application No. 09/765,491                                                                           

                 the rejection of claim 10 as obvious in view of Aggarwal.  Claims 11, 12,                            
                 and 18 fall with claim 10.                                                                           
                 6.  OBVIOUSNESS:  CLAIMS 10-12 AND 19                                                                
                        Claims 10-12 and 19 stand rejected under 35 U.S.C. § 103 as obvious                           
                 over Arbiser,9 Thaloor,10 and Aggarwal.  As noted above, claims 10-12 and                            
                 19 were not argued separately and therefore stand or fall together.  Since we                        
                 have already determined that claim 10 would have been obvious in view of                             
                 Aggarwal alone, we agree with the Examiner that claim 10 would have been                             
                 obvious in view of Arbiser, Thaloor, and Aggarwal.                                                   
                        Appellant argues that “[t]here is no disclosure or suggestion in Arbiser                      
                 1998 of the formulation used in claim 10.  Neither Thaloor nor Agg[ar]wal                            
                 make up this deficiency.”  (Reply Br. 10.)                                                           
                        This argument is unpersuasive because, for the reasons discussed                              
                 above, Aggarwal would have suggested the formulation recited in claim 10.                            

                                                                                                                     
                 9 In the Answer, Arbiser is cited as follows:  “Arbiser et al. ‘The                                  
                 antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth                              
                 of angiosarcoma in mice’.  J. Am. Acad. Dermatol., 1999, June; 40 (6t                                
                 1):925-9.”  As Appellant recognized, “it appears that the Examiner is                                
                 discussing the subject matter of Arbiser, et al., Molecular Medicine,                                
                 4(3):191-195 (1998) (‘Arbiser 1998’).”  (Reply Br. 10.)  We agree with                               
                 Appellant that the Examiner’s rejection relies on Arbiser 1998, not the                              
                 Arbiser 1999 reference cited in the Answer.  Arbiser 1998 was cited in the                           
                 Form PTO-892 that accompanied the Office action mailed Nov. 4, 2003.                                 
                 Since Appellant appreciated the correct basis of the rejection and responded                         
                 to it in the Reply Brief, we see no need to remand the application for the                           
                 Examiner to clarify the record.                                                                      
                 10 Thaloor et al., “Inhibition of angiogenic differentiation of human                                
                 umbilical vein endothelial cells by curcumin,” Cell Growth &                                         
                 Differentiation, Vol. 9, pp. 305-312 (1998).                                                         
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