Appeal 2007-0537
Application 10/102,902
20. According to the Specification, “features may be considered
generalizations of CoMMA descriptors that characterize local regions of the
property field by its local moments.” (Spec. 19; see also Answer 12.)
“Atta-ur-Rahman shows that chemical shifts of compounds” are features (or
descriptors) that “have moment-based aspects to them” and are “invariant
under coordinate system transformations.” (Answer 12 (citing Atta-ur-
Rahman 8-10).)
21. “Cluster analysis of protein sequences for representing distance
data has been commonly used by biologists for a long time . . . .” (Aude 303
(cited in Answer 13).)
Additional Findings
22. Field-based similarity search methods are known in the art, as are
computer systems and methods employing a “database,” an “input device,” a
“processor,” and a “display device.” (Spec. 2-5 (citing pages of prior art
systems and methods); see also Spec. 74 & Fig. 27 (illustrating conventional
computer system components).)
23. Numerous methods of molecular superposition, i.e., aligning
molecular structures also are known in the art. (See Spec. 2, 48-49;
Cornilescu 293 (Fig. 1 showing detection of “missing alignments”).)
24. With respect to context-adaptive scaling techniques, “there is a
vast repertoire of methods from the disciplines of classification and pattern
recognition” to provide such scaling, including “Fisher’s linear discriminant
analysis”. (Spec. 34.)
25. The skilled artisan, interested in searching with a computer for
homologous proteins, would have had a reason to utilize the teachings of
Cornilescu to do so in view of Cornilescu’s express teaching that
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