Appeal 2007-0537 Application 10/102,902 wherein said features of said candidate molecule fragment pair and query molecule fragment pair comprise descriptors, said processor performing context-adaptive scaling of said descriptors. (Claim 1 (emphasis added to the disputed clause) (App. Br. 11; Reply Br. 1- 4).) The Examiner has rejected all the pending claims, claims 1-27, under 35 U.S.C. § 103(a) as follows: Claims 1-4, 6-10, 12-19, 21-23, and 25-26 over Cornilescu et al., Protein backbone angle restraints from searching a database for chemical shift and sequence homology, 13 J. Biomolecular NMR 289-302 (1999) (hereafter “Cornilescu”), and Gilhuijs et al., U.S. Patent No. 6,317,617 (issued Nov. 13, 2001) (hereafter “Gilhuijs”); Claims 1, 11, 14, 20, 24, and 27 over Cornilescu, Gilhuijs, and Atta- ur-Rahman, Nuclear Magnetic Resonance: Basic Principles 8-10 (Springer- Verlag 1986) (hereafter “Atta-ur-Rahman”); and Claim 5 over Cornilescu, Gilhuijs, and Aude et al., Applications of pyramidal clustering method to biological objects, 23 Computers & Chemistry 303-15 (1999). PATENTABILITY UNDER § 103(a) Claim 1 The patentability of claim 1 turns on the meaning of the claim phrase “features of said candidate molecule fragment pair and query molecule fragment pair comprise descriptors, said processor performing context- adaptive scaling of said descriptors.” More specifically, it turns on the meaning of “features,” “fragment pair,” “context-adaptive scaling,” and 3Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Next
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