Ex Parte Cuthbertson et al - Page 10

                Appeal No. 2007-1140                                                                         
                Application No. 10/753,729                                                                   

                      Appellants also argue that “Cuthbertson teaches that a linker moiety is                
                responsible for modifying the pharmacokinetics or blood clearance rates.”                    
                (Reply Br. 4.)  But Cuthbertson also teaches that the linker moiety can be                   
                present without the reporter (“X8 . . . is NH2 or absent”) (Cuthbertson 9:                   
                10-15). Thus, we do not agree that this difference distinguishes the claimed                 
                invention from Cuthbertson.                                                                  
                      Secondary considerations                                                               
                      “One way for a patent applicant to rebut a prima facie case of                         
                obviousness is to make a showing of ‘unexpected results,’ i.e., to show that                 
                the claimed invention exhibits some superior property or advantage that a                    
                person of ordinary skill in the relevant art would have found surprising or                  
                unexpected.”  In re Soni, 54 F.3d 746, 750, 34 USPQ2d 1684, 1687 (Fed.                       
                Cir. 1995).                                                                                  
                      An applicant cannot prove unexpected results with attorney                             
                      argument and bare statements without objective evidentiary                             
                      support. See In re Lindner, 59 C.C.P.A. 920, 457 F.2d 506, 508                         
                      (CCPA 1972); In re Geisler, 116 F.3d 1465 (Fed. Cir. 1997)                             
                      (“attorney argument [is] not the kind of factual evidence that is                      
                      required to rebut a prima facie case of obviousness”); In re                           
                      Soni, 54 F.3d 746, 750 (Fed. Cir. 1995) (“It is well settled that                      
                      unexpected results must be established by factual evidence.                            
                      Mere argument or conclusory statements ... [do] not suffice.”)                         
                      (quoting In re De Blauwe, 736 F.2d 699, 705 (Fed.Cir.1984)).                           
                CFMT Inc. v. Yieldup Inter’l Corp., 349 F.3d 1333, 1342, 68 USPQ 2d                          
                1940, 1947 (Fed. Cir. 2003).                                                                 
                      In this case, we find no evidentiary support for Appellants’ statement                 
                that the results obtained with “present invention” are “unexpectedly” better                 
                and “superior” when compared to Cuthbertson’s compounds (Substitute Br.                      


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