Appeal 2007-1378
Application 10/327,459
1 wherein the Carr’s Compressibility Index, of the dry blend, is
2 less than about 34%;
3 wherein said non-dihydrate azithromycin is azithromycin
4 monohydrate hemi-ethanol solvate.
5
6 Tenengauzer
7 Tenengauzer relates to stabilized azithromycin compositions.
8 Col. 1:13-14; col. 3:1-2.
9 One suitable particular azithromycin is azithromycin ethanolate
10 monohydrate. Col. 3:2-6.
11 Pharmaceutical compositions comprising the stabilized azithromycins
12 include dosage forms such as tablets. Col. 4:35-37.
13 While other dosage forms are described, according to Tenengauzer
14 among the methods for forming preferred tablet dosage forms are dry
15 granulation (compaction and slugging) and direct compression.
16 Col. 4:41-43.
17
18 Singer
19 Singer describes azithromycin ethanolate which can be formed into
20 tablets and compressed or coated pills. Col. 3:24-27
21 An Example in Singer describes preparation of azithromycin
22 ethanolate. Col. 3:54.
6
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Last modified: September 9, 2013