Ex Parte Keen et al - Page 2

                  Appeal 2007-1689                                                                                           
                  Application 10/431,627                                                                                     

                         Claim 1 illustrates Appellants’ invention of an apparatus for automatic                             
                  polynucleotide synthesis, and is representative of the claims on appeal:                                   
                         1.  An apparatus for maintaining a closed continuous anhydrous                                      
                  system for automated polynucleotide synthesis, comprising: a) a plurality of                               
                  moisture-resistant reagent containers, b) a dry box capable of forming a seal                              
                  over a synthesis platform of an automated polynucleotide synthesizer, c)                                   
                  moisture-resistant tubing connecting said reagent containers to said dry box,                              
                  d) a reagent gas feed connecting said reagent containers to a gas, wherein                                 
                  said gas pressurizes said reagent containers, and e) a digital gas regulator                               
                  connected to said reagent gas feed, wherein said gas regulator maintains                                   
                  constant pressure in said reagent containers.                                                              
                         The Examiner relies on the evidence in these references:                                            
                  Penhasi1    US 3,725,010          Apr.   3, 1975                                                           
                  Bardman    US 2003/0236374 A1         Dec. 25, 2003                                                        
                         Appellants request review of the following grounds of rejection under                               
                  35 U.S.C. § 103(a) advanced on appeal (Br. 4):                                                             
                  Claims 1 through 3, 5 through 13, and 15 through 20 as unpatentable over                                   
                  Penhasi (Answer 3); and                                                                                    
                  claims 4 and 14 as unpatentable over Penhasi in view of Bardman (id. 5).                                   
                         Appellants argue the claims in each ground of rejection as a group                                  
                  (Br. in entirety).  Thus, we decide this appeal based on claims 1 and 4.                                   
                  37 C.F.R. § 41.37(c)(1)(vii) (2006).                                                                       
                         The issues in this appeal are whether the Examiner has carried the                                  
                  burden of establishing a prima facie case in each of the grounds of rejection                              
                  advanced on appeal.                                                                                        



                                                                                                                            
                  1  We find that in fact US 3,725,010 issued to Harry A. Penhasi (see Penhasi                               
                  col. 1, l. 4).                                                                                             
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