Appeal 2007-1689 Application 10/431,627 Claim 1 illustrates Appellants’ invention of an apparatus for automatic polynucleotide synthesis, and is representative of the claims on appeal: 1. An apparatus for maintaining a closed continuous anhydrous system for automated polynucleotide synthesis, comprising: a) a plurality of moisture-resistant reagent containers, b) a dry box capable of forming a seal over a synthesis platform of an automated polynucleotide synthesizer, c) moisture-resistant tubing connecting said reagent containers to said dry box, d) a reagent gas feed connecting said reagent containers to a gas, wherein said gas pressurizes said reagent containers, and e) a digital gas regulator connected to said reagent gas feed, wherein said gas regulator maintains constant pressure in said reagent containers. The Examiner relies on the evidence in these references: Penhasi1 US 3,725,010 Apr. 3, 1975 Bardman US 2003/0236374 A1 Dec. 25, 2003 Appellants request review of the following grounds of rejection under 35 U.S.C. § 103(a) advanced on appeal (Br. 4): Claims 1 through 3, 5 through 13, and 15 through 20 as unpatentable over Penhasi (Answer 3); and claims 4 and 14 as unpatentable over Penhasi in view of Bardman (id. 5). Appellants argue the claims in each ground of rejection as a group (Br. in entirety). Thus, we decide this appeal based on claims 1 and 4. 37 C.F.R. § 41.37(c)(1)(vii) (2006). The issues in this appeal are whether the Examiner has carried the burden of establishing a prima facie case in each of the grounds of rejection advanced on appeal. 1 We find that in fact US 3,725,010 issued to Harry A. Penhasi (see Penhasi col. 1, l. 4). 2Page: Previous 1 2 3 4 5 6 7 8 9 Next
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