Ex Parte Stryer et al - Page 5

                Appeal 2007-1819                                                                             
                Application 09/886,055                                                                       
                functions associated with sensory perception at the level of ligand-receptor                 
                binding” (Specification 2-3).                                                                
                      Claim 23 is drawn to a method for representing sensory perception of                   
                one or more odorants.  Claims 24-33 depend from claim 23.                                    
                      Appellants’ claimed method comprises three steps:                                      
                      (a)  providing a representative class of n olfactory receptors or ligand-              
                binding domains thereof;                                                                     
                      (b) measuring X1 to Xn representative of at least one activity of one or               
                more odorants; and                                                                           
                      (c) generating a representation of sensory perception from the values                  
                X1 to Xn.                                                                                    
                      According to claim 23, the representation of at least one activity of an               
                odorant is determined by the odorant’s ability to                                            
                      (1) bind to the ligand-binding domain of at least one of the n olfactory               
                      receptors,                                                                             
                      (2) activate at least one of the n olfactory receptors, or                             
                      (3) block at least one of the n olfactory receptors.                                   
                      In addition, claim 23 requires that at least one of the n olfactory                    
                receptors has the amino acid sequence contained in SEQ ID NO: 55.                            
                Claims 24-33 depend from claim 23.                                                           
                      Claims 23-33 stand rejected under 35 U.S.C. § 103(a) as unpatentable                   
                over the combination of Krautwurst and Burford.  The Examiner finds that                     
                “Krautwurst teaches the method steps of claim 23” (Answer 4).  The                           
                Examiner recognizes, however, that Krautwurst does not teach, inter alia, an                 
                olfactory receptor having the sequence set forth in SEQ ID NO. 55 (Answer                    



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