Ex Parte Graf et al - Page 11

               Appeal  2007-2018                                                                            
               Application  09/810,377                                                                      

               “to modify the tungsten in Parker to be of a size at least as small as                       
               0.9 microns and larger as such are known particle sizes of tungsten used in                  
               radiopaque catheters as suggested by Hopkins as such would be more easily                    
               visible” (id.).                                                                              
                      We conclude that the Examiner has set forth a prima facie case of                     
               obviousness.  Parker and Coneys are discussed above.  For the reasons                        
               discussed above, we agree with the Examiner that one of ordinary skill in the                
               art would have been motivated to replace the polyether block amide in both                   
               the shaft and distal tip section of Parker’s device with the polyfluorinated                 
               ethylenepropylene described in Coneys, and to include between about 50%                      
               and 55% by weight tungsten particles in the distal tip.                                      
                      Hopkins describes a catheter comprising a plastic material containing                 
               tungsten particles that are no greater than 2 microns in size (Hopkins,                      
               Abstract).  Hopkins states that “tungsten is preferred for its low cost, high                
               radiopaqueness and its availability in particles as small as 0.9 microns” (id.               
               at col. 2, ll. 28-31).  Based on the teachings in Hopkins, we also agree that it             
               would have been obvious to include tungsten particles that range in size                     
               from 0.9 to 2.0 microns in the distal tip.  “[W]here there is a range disclosed              
               in the prior art, and the claimed invention falls within that range, there is a              
               presumption of obviousness.”  Iron Grip Barbell, 392 F.3d at 1322, 73                        
               USPQ2d at 1228.                                                                              
                      Appellants argue that “the combination of Parker and Coneys neither                   
               teaches nor suggests the use of highly loaded FEP as a distal tip material.                  
               Furthermore, the cited combination neither teaches nor suggests a distal tip                 
               section containing between about 50% and 55% by weight of tungsten                           


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