Ex Parte Muller et al - Page 8

                  Appeal 2007-2524                                                                                         
                  Application 10/194,834                                                                                   
                  amount of ciprofloxacin is 0.35 wt. %, it is our opinion that a composition                              
                  comprising 0.35 wt % ciprofloxacin and which is free of preservative is                                  
                  sufficiently described by Cagle to constitute anticipation under 35 U.S.C. §                             
                  102(b) just as if it were explicitly written down in a single example.                                   
                         Appellants contend that Cagle does not anticipate the claimed                                     
                  invention because Examples 1 and 3, which contain 0.35% ciprofloxacin,                                   
                  contains the preservative benzalkonium chloride (BAC) and thus are not                                   
                  “free of any other component effective as a preservative” (Br. 11).                                      
                  Appellants argue that the Examiner’s assertion that Cagle’s claim 1                                      
                  describes a composition which is free of BAC is erroneous since “the                                     
                  disclosure of Cagle et al. does not contain any reference to compositions                                
                  comprising a quinoxaline and an ophthalmically acceptable carrier which                                  
                  lack a secondary preservative, the claims of Cagle cannot be interpreted to                              
                  encompass this negative limitation” (Reply Br. 5).                                                       
                         Appellants’ argument appears to be that the skilled worker would not                              
                  have read the ciprofloxacin composition of claim 1 to be free of preservative                            
                  since all Cagle’s examples of a useful therapeutic ciprofloxacin composition                             
                  include the preservative BAC.  We do not find this argument persuasive.                                  
                         Appellants have introduced no evidence that a skilled worker, reading                             
                  claim 1 of Cagle, would have understood it to require the presence of a                                  
                  preservative.  Arguments of counsel cannot take the place of evidence                                    
                  lacking in the record.  Estee Lauder Inc. v. L’Oreal, S.A., 129 F.3d 588, 595,                           
                  44 USPQ2d 1610, 1615 (Fed. Cir. 1997).  To the contrary, we find sufficient                              
                  evidence of record to support the Examiner’s finding that Cagle describes a                              
                  composition that anticipates the claimed invention.                                                      



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