Ex Parte Goddard et al - Page 2

                Appeal 2007-2953                                                                              
                Application 10/175,749                                                                        

                lacking patentable utility.  We have jurisdiction under 35 U.S.C. § 6(b).  We                 
                affirm.                                                                                       
                                              BACKGROUND                                                      
                      The specification discloses 305 DNA sequences and the encoded                           
                amino acid sequences.  Pages 6-38.  Among the disclosed sequences is SEQ                      
                ID NO:73, which encodes a polypeptide referred to as “PRO700” having the                      
                amino acid sequence shown in SEQ ID NO:74.  Page 10 and Figure 74.  The                       
                encoded amino acid sequence is disclosed to include a signal sequence.                        
                Figure 74.                                                                                    
                      The present specification does not further characterize the amino acid                  
                sequence of SEQ ID NO:74.  However, the present application claims                            
                priority as follows:                                                                          
                      This application is a continuation of . . . a continuation of . . . a                   
                      continuation-in-part  of  . . .  a  continuation-in-part  of  . . .  US                 
                      Application 09/380138 filed 8/25/1999, now abandoned, which                             
                      is  the  National    Stage  filed  under  35  USC  §371  of  PCT                        
                      Application  PCT/US99/05028  filed  3/18/1999,  which  claims                           
                      priority under 35 USC § 119 to  US  provisional  application                            
                      60/080333 filed 4/1/1998.                                                               
                (Preliminary Amendment received Sept. 18, 2002, at 1-2.)                                      
                      PCT application US99/05028 was published as WO 99/46281 on                              
                Sept. 16, 1999.  Thus, the contents of that application were known to those                   
                of ordinary skill in the art as of that date.  WO 99/46281 characterizes                      
                PRO700 as follows:                                                                            
                      13.  PRO700                                                                             
                      Protein-disulfide  isomerase  (PDI)  is  a  catalyst  of  disulfide                     
                      formation and isomerization during protein folding.  It has two                         
                      catalytic sites housed in two domains homologous to                                     

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