Appeal 2007-2953
Application 10/175,749
thioredoxin, one near the N terminus and the other near the C
terminus. . . . PDI is useful for formation of natural type
disulfide bonds in a protein which is produced in a[ ]
prokaryotic cell. (See also, U. S. Patent Nos. 5,700,659 and
5,700,678).
Thus, PDI and molecules related thereto are of interest,
particularly for ability to catalyze the formation of disulfide
bonds. Moreover, these molecules are generally of interest in
the study of redox reactions and related processes. PDI and
related molecules are further described in Darby, et al.,
Biochemistry 34, 11725-11735 (1995). We herein describe the
identification and characterization of novel polypeptides having
homology to protein disulfide isomerase, designated herein as
PRO700 polypeptides.
(WO 99/46281, at 9.)
DISCUSSION
1. CLAIMS
Claims 25-32 and 35-37 are pending and on appeal. The claims have
not been argued separately and therefore stand or fall together. 37 C.F.R.
§ 41.37(c)(1)(vii). Claim 25 is the only independent claim and reads as
follows:
25. An isolated polypeptide having at least 80% amino acid
sequence identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO: 74;
(b) the amino acid sequence of the polypeptide of SEQ ID NO: 74,
lacking its associated signal peptide; or
(c) the amino acid sequence of the polypeptide encoded by the full-
length coding sequence of the cDNA deposited under ATCC accession
number 209721,
wherein said polypeptide has protein disulfide isomerase activity.
3
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