Ex Parte Syverson et al - Page 4

               Appeal 2007-3216                                                                            
               Application 10/271,433                                                                      
               B2.  Brown-Skrobot states: “there is a need to find a douche composition                    
               which is able to combat the production of TSST-1 by Staphylococcus aureus                   
               within the vaginal cavity” (Brown-Skrobot, at col. 3, ll. 48-50).                           
               B3.  Brown-Skrobot describes a douche composition comprising mono or                        
               diesters of polyhydric aliphatic alcohols (e.g. glyceryl monolaurate) that is               
               able to combat the production of TSST-1 by Staphylococcus aureus (a                         
               Gram-positive bacteria) within the vaginal cavity (Brown-Skrobot, at                        
               Abstract; col. 3, ll. 54-67; col. 5, 1l. 5-7 and 40-48; col. 6, ll. 12-23; see              
               Answer 3).                                                                                  
               Mitra                                                                                       
               M1.  Mitra describes topical moisturizing wipes for treating microbial                      
               infections (Mitra, at col. 2, ll. 16-19).                                                   
               M2.  The wipes can comprise effective amounts of antimicrobial compounds                    
               (Mitra, at col. 2, ll. 25-29).                                                              
               M3.  Mitra lists various antimicrobial compounds that are described as being                
               effective against various human and animal pathogens, including                             
               Staphylococcus aureus (Mitra, at col. 3, ll. 14-16; Answer 4).                              
               M4.  Hexachlorophene (“2-2’-dihydroxy-3,3’,5,5’,6,6’-                                       
               hexachlorodiphenylmethane”) is listed as a suitable antimicrobial agent                     
               (Mitra, at col. 3, l. 29; Answer 4) for its topical wipes.                                  
               M5.  The wipes can be used for “treatment of dry membranous tissue . . .                    
               and healthy membranous tissue” (Mitra, at col. 2, ll. 34-39).                               
               M6.  “For treatment, the wipe composition is applied to the mucosal skin via                
               topical application of a safe and effective amount of composition to treat an               
               existing fungal, microbial or protozoal growth” (Mitra, at col. 10, ll. 52-55).             



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