Ex Parte Syverson et al - Page 10

               Appeal 2007-3216                                                                            
               Application 10/271,433                                                                      
               rejection, which is to incorporate antimicrobial active agents disclosed by                 
               Mitra et al., and not the entire topical composition, into the feminine                     
               compositions” of Brown-Skrobot (Answer 7).                                                  
                      For the foregoing reasons, we affirm the rejection of claim 1.  Claims               
               4 and 5 fall with claim 1 because their patentability was not separately                    
               argued.  See 37 C.F.R. § 41.37(c)(1)(vii).                                                  

                      Claims 41-43                                                                         
                      Claims 41-43 are directed to the method of claim 1 in which the active               
               agent is present in a specifically recited amount.  The Examiner contends                   
               that                                                                                        
                      it would have been obvious to one of ordinary skill in the art to                    
                      optimize the antimicrobial activity of the composition of the                        
                      combined references such that the desired inhibition of TSST-1                       
                      production is achieved.  “[W]here the general conditions of a                        
                      claim are disclosed in the prior art, it is not inventive to                         
                      discover the optimum or workable ranges by routine                                   
                      experimentation.”  In re Aller, 220 F.2d 454, 456, 105 USPQ                          
                      233, 235 (CCPA 1955).                                                                
               (Answer 5.)                                                                                 
                      Appellants argue that the amounts described in Mitra are                             
               “significantly higher than the amount of first active ingredient claimed in . . .           
               claims 41-43” (App. Br. 14).                                                                
                      We do not find this argument persuasive.  As pointed out by the                      
               Examiner, after teaching specific amounts of antimicrobial ingredients,                     
               Mitra states that the “level is selected to provide the desired level of                    
               antimicrobial activity and can be modified as desired” (Mitra, at col. 3, ll. 5-            
               7).  This supports the Examiner’s argument that determining the effective                   
               amounts of an antimicrobial would have been routine experimentation                         

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