Appeal 2007-3216 Application 10/271,433 rejection, which is to incorporate antimicrobial active agents disclosed by Mitra et al., and not the entire topical composition, into the feminine compositions” of Brown-Skrobot (Answer 7). For the foregoing reasons, we affirm the rejection of claim 1. Claims 4 and 5 fall with claim 1 because their patentability was not separately argued. See 37 C.F.R. § 41.37(c)(1)(vii). Claims 41-43 Claims 41-43 are directed to the method of claim 1 in which the active agent is present in a specifically recited amount. The Examiner contends that it would have been obvious to one of ordinary skill in the art to optimize the antimicrobial activity of the composition of the combined references such that the desired inhibition of TSST-1 production is achieved. “[W]here the general conditions of a claim are disclosed in the prior art, it is not inventive to discover the optimum or workable ranges by routine experimentation.” In re Aller, 220 F.2d 454, 456, 105 USPQ 233, 235 (CCPA 1955). (Answer 5.) Appellants argue that the amounts described in Mitra are “significantly higher than the amount of first active ingredient claimed in . . . claims 41-43” (App. Br. 14). We do not find this argument persuasive. As pointed out by the Examiner, after teaching specific amounts of antimicrobial ingredients, Mitra states that the “level is selected to provide the desired level of antimicrobial activity and can be modified as desired” (Mitra, at col. 3, ll. 5- 7). This supports the Examiner’s argument that determining the effective amounts of an antimicrobial would have been routine experimentation 10Page: Previous 1 2 3 4 5 6 7 8 9 10 11 Next
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