Ex Parte Liu et al - Page 5

                Appeal 2007-3390                                                                             
                Application 10/143,915                                                                       
                      3.  providing vitamin C to the Keratinocyte cells located in the                       
                epidermis layers of the skin enabling the vitamin C to expel Melanin from                    
                the Keratinocyte cells.                                                                      
                      The Examiner relies on Kim to teach a method for the transdermal                       
                administration of vitamin C (ascorbic acid) wherein vitamin C is penetrated                  
                into the skin using iontophoresis and ultrasonic waves (Answer 4; Kim                        
                Abstract).                                                                                   
                      In addition, we find that Kim teaches an ultrasonic device.                            
                Specifically, Kim teaches a skin-care apparatus that comprises, inter alia, a                
                resonance part that produces ultrasonic waves and an iontophoresis-vibration                 
                part, “which enables iontophoresis and ultrasonic massage to be conducted                    
                by way of a contact plate that is in contact with skin” (Kim 4: 17 - 5: 6).                  
                According to Kim the method for transdermal administration of ascorbic                       
                acid is preferably conducted by iontophoresis, while applying ultrasonic                     
                vibrations to the skin (Kim 9: 17-22).  Stated differently, Kim’s method for                 
                transdermal administration of ascorbic acid is performed with an ultrasonic                  
                device.                                                                                      
                      We recognize the Examiner’s statement that Kim “does not teach                         
                expressly using ultrasonic [waves] as the means for enhancing penetration”                   
                (Answer 4).  This is, however, not required by claim 4.  Claim 4 simply                      
                requires the use of an “ultrasonic device”.  As discussed above, Kim                         
                discloses an ultrasonic device.  Nevertheless, the Examiner relies on Spencer                
                to teach that iontophoresis (which utilizes electrical potential energy) and                 
                sonophoresis (which utilizes ultrasonic waves) are both known in the art to                  
                be useful for enhancing the skin’s absorption of topical actives (Answer 4).                 



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