Ex parte PERSHADSINGH et al. - Page 2




               Appeal No. 95-0885                                                                                                  
               Application 07/725,327                                                                                              


                                                 The Claimed Subject Matter                                                        
                       The claims on appeal are directed to a method for controlling essential hypertension and its                
               related cardiovascular syndrome in a mammalian host.  Claims 1 and 18 are illustrative of subject                   
               matter appellants regard as their invention:                                                                        
                       1.  A method for controlling essential hypertension and its related cardiovascular                          
                       syndrome in a mammalian host in need thereof by administration of an effective                              
                       amount of a 5-aryl substituted thiazolidine derivative of formula I                                         






                                                                                                                                  
                                                                                                    I                              
                                                                                                                                  


                                                                                                                                  


                       where: R  is an aromatic carbocyclic or an aromatic heterocyclic;                                           
                                1                                                                                                  
                       X is a lower alkylidene or a bond; or -HC=CH-                                                               
                       Y is oxo or imino;                                                                                          
                       Z is oxo or imino;                                                                                          
                       and pharmaceutically acceptable salts thereof with the proviso that R  is not of the                        
                                                                                             1                                     
                       formula                                                                                                     

                                                                -2-                                                                





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