Ex parte BOUFFARD et al. - Page 9




          Appeal No. 95-3387                                                          
          Application No. 08/005,942                                                  


          need be said by appellants in relation to the obviousness-type              
          double patenting rejection at this stage of prosecution.                    
                         Rejections based on 35 U.S.C. § 103                          
               Claims 1-15 stand rejected under 35 U.S.C. § 103 over                  
          Schmatz alone or in the alternative over '310 Pat. or '067                  
          Pat. in combination with Michel.                                            




               The examiner's grounds of rejection are set forth on                   
          pages                                                                       
          4 and 5 of the Examiner's Answer to which we refer for the                  
          examiner's presentation of the reasons for rejection.                       
               Schmatz discloses a genus of compounds which is inclusive              
          of a number of species contained within the genus of claim 1                
          herein, with the exception of the hydroxyproline residue.                   
          Schmatz discloses a 3-hydroxy-4-methylproline, while the                    
          instantly claimed compounds do not contain a methyl group on                
          the 4th carbon of the proline residue.  Appellants pointed to               
          this distinction in response to the first action and submitted              
          two declarations pursuant to 37 CFR § 1.132.  The declarations              
          address properties of hexapeptidyl echinocandin derivatives                 
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