Appeal No. 95-4464
Application 07/605,788
olfactory epithelium could be used as source of living nerve
cells for the study of Alzheimer’s disease provided “they can be
shown to have the characteristics of this disease.” Talamo,
p. 736, para. 1. Specifically, Talamo states that because
olfactory neurons “have the unusual property of arising from stem
cells throughout the life of the organism, they are good
candidates for the development of cell cultures or cell lines
which may express the disorder from living patients.” Id.
Coon discloses a method of isolating and culturing
neuroblasts derived from rat olfactory epithelium. Coon,
p. 1703, the abstract.
Wolozin discloses the preparation of a monoclonal antibody
(Alz-50) which recognizes a single antigen (with a molecular
weight of 68,000) which is said to be present in much higher
concentrations in certain regions of the brain of Alzheimer’s
patients than in normal brain. Wolozin, p. 232, the abstract.
Cole discloses that the platelets of Alzheimer’s patients
can be stimulated with thrombin or ionomycin to secrete soluble
truncated amyloid $-protein precursor (APP) and particulate
membrane fragments which contain C-terminal and N-terminal
immunoreactive amyloid $-protein precursor. Cole, p. 288,
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