Appeal No. 95-4464
Application 07/605,788
expected that neuroblasts derived from AD patients and cultured
in vitro to express AD-specific markers.
Thus, even if we assume, arguendo, that the culturing of
human olfactory neurons would have been obvious to one of
ordinary skill in the art in view of the teachings of Talamo and
Coon, the question remains as to whether the neuroblasts derived
from AD patients would, after their adaptation to tissue culture
conditions and/or differentiation in vitro, express AD-specific
markers. Here, the appellants have presented evidence that the
phenotype and genotype of animal cells may be altered when they
are placed in culture. Thus, on this record, it appears that3
the mere fact that Talamo reports that the neurotic masses in
olfactory epithelium comprising differentiated cells derived from
AD patients and taken at autopsy, could be stained with the AD-
specific monoclonal antibody, ALZ-50, would not necessarily have
suggested that neuroblasts derived from AD patients, or neuro-
blasts from AD patients and placed in culture, would express the
antigen recognized by ALZ-50.
Similarly, even if we assume, arguendo, that the culturing
3The appellants have submitted an excerpt from the textbook
Microbiology, Second Edition, Davis, et al., Harper & Row,
publishers, NY, p. 1122 (1973).
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