Ex parte WOLOZIN et al. - Page 8




          Appeal No. 95-4464                                                          
          Application 07/605,788                                                      



          of human olfactory neurons would have been obvious to one of                
          ordinary skill in the art in view of the teachings of Talamo and            
          Coon, it would appear, on this record, that the mere fact that              
          Talamo observed morphological differences and staining with the             
          monoclonal antibody ALZ-50 in olfactory neurons taken from AD               
          patients at autopsy, would not necessarily have suggested to                
          those of ordinary skill in the art the release of APP from                  
          neuroblasts derived from AD patients, or neuroblasts from AD                
          patients and placed in culture, in response to an ionophore as              
          described by Cole.                                                          
               Accordingly, on this record, we reverse the examiner’s                 
          rejection.                                                                  
               The decision of the examiner is reversed.                              
                                      REVERSED                                        


                         RONALD H. SMITH               )                              
                         Administrative Patent Judge   )                              
                                                       )                              
                                                       )                              
                                                       ) BOARD OF PATENT              
                         WILLIAM F. SMITH             )   APPEALS AND                 
                         Administrative Patent Judge   ) INTERFERENCES                
                                                       )                              
                                                       )                              
                                                       )                              
                         JOAN ELLIS                    )                              
                         Administrative Patent Judge   )                              

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