Appeal No. 94-1573 Paper No. 24
Application No. 07/552,744 Page 3
Plasmodium falciparum, 17 Nucleic Acids Res. 8382
(1989) (Vasanthakumar I);
2. Claims 2-4 under 35 U.S.C. § 102(b) as anticipated
by-
A. King & D.W. Melton, Characterization of cDNA
Clones for hypoxanthine-guanine phosphoribosyltrans-
ferase from the human malarial parasite, Plasmodium
falciparum: Comparisons to the mammalian gene and
protein, 15 Nucleic Acids Res. 10469-10481 (1987)
(King); and
3. Claims 1-7 under 35 U.S.C. § 103 as unpatentable
over the combination of King and the following additional
references-
D.B. Smith, M.R. Rubira, R.J. Simpson, K.M. Davern,
W.U. Tiu, P.G. Board, & G.F. Mitchell, Expression of
an enzymatically active parasite molecule in
Escherichia coli: Schistosoma japonicum glutathione
S-transferase, 27 Molecular & Biochemical
Parasitology 249-256 (1988) (Smith),
G. Vasanthakumar & R.L. Davis, Jr., Cloning and
expression of the hypoxanthine-guanine
phosphoribosyltransferase gene from Plasmodium
falciparum in E. coli, J. of Cellular Biochem.,
Abstracts of the 18th Annual Meetings, Supp. 13 E at
125 (1989) (Vasanthakumar II),
P. Marsh, Ptac, an E. coli Vector for Expression of
Non-Fusion Proteins, 14 Nucleic Acids Res. 3603
(1986) (Marsh), and
C.N. Remy & M.S. Smith, Metabolism of 2,6-Diamino-
purine Conversion to 5'-Phosphoribosyl-2-
Methylamino- 6-Aminopurine by Enzymes of
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