Ex parte VASANTHAKUMAR et al. - Page 7




          Appeal No. 94-1573                                   Paper No. 24           
          Application No. 07/552,744                                 Page 7           


          hypoxanthine-guanine phosphoribosyltransferase (HGPRT)                      
          activity in P. falciparum.  King was unable to express the                  
          protein product and did not detect and characterize the                     
          activity of any protein product of King's sequence.  It                     
          follows that King does not establish with any degree of                     
          certainty that King's cDNA sequence would encode a protein                  
          exhibiting HGPRT activity.  One skilled in the art might                    
          conclude that King's cDNA could express a protein exhibiting                
          HGPRT activity.  Inherency, however, may not be established by              
          probabilities or possibilities.  The fact that a result might               
          occur in a specific set of circumstances is not sufficient.                 
          Mehl/Biophile Int'l Corp. v. Milgraum,  __ F. 3d __, __,                    
          52 USPQ2d 1303, 1305 (Fed. Cir. 1999).                                      
               The examiner has not established that King's cDNA                      
          inherently encodes a protein that would exhibit HGPRT                       
          activity, so the rejection of claim 2 under § 102(b) is                     
          reversed.  Claim 3 requires the same HGPRT activity as claim                
          2, and claim 4 depends from claim 3, so the rejection of these              
          claims must be reversed as well.                                            










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