Appeal No. 94-1573 Paper No. 24
Application No. 07/552,744 Page 12
Appendix
1. An isolated and purified dimeric protein having a
molecular weight of about 52,000 daltons and having
substantially the following amino acid residue sequence:
Met Pro Ile Pro Asn Asn Pro Gly Ala Gly Glu Asn Ala Phe
Asp Pro Val Phe Val Lys Asp Asp Asp Gly Tyr Asp Leu Asp
Ser Phe Met Ile Pro Ala His Tyr Lys Lys Tyr Leu Thr Lys
Val Leu Val Pro Asn Gly Val Ile Lys Asn Arg Ile Glu Lys
Leu Ala Tyr Asp Ile Lys Lys Val Tyr Asn Asn Glu Glu Phe
His Ile Leu Cys Leu Leu Lys Gly Ser Arg Gly Phe Phe Thr
Ala Leu Leu Lys His Leu Ser Arg Ile His Asn Tyr Ser Ala
Val Glu Thr Ser Lys Pro Leu Phe Gly Glu His Tyr Val Arg
Val Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly Thr Leu Glu
Ile Val Ser Glu Asp Leu Ser Cys Leu Lys Gly Lys His Val
Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Leu Val
Lys Phe Cys Glu Tyr Leu Lys Lys Phe Glu Ile Lys Thr Val
Ala Ile Ala Cys Leu Phe Ile Lys Arg Thr Pro Leu Trp Asn
Gly Phe Lys Ala Asp Phe Val Gly Phe Ser Ile Pro Asp His
Phe Val Val Gly Tyr Ser Leu Asp Tyr Asn Glu Ile Phe Arg
Asp Leu Asp His Cys Cys Leu Val Asn Asp Glu Gly Lys Lys
Lys Tyr Lys Ala Thr Ser Leu.
2. A cDNA sequence encoding for Plasmodium falciparum
HGPRT.
3. A purified isolated DNA sequence consisting
essentially of a DNA sequence coding for the protein having
the amino acid residue sequence according to Claim 1 or for a
protein having substantially the same amino acid sequence and
substantially the same HGPRT activity as the protein defined
in Claim 1.
4. A purified isolated DNA sequence according to Claim 3
wherein one such sequence is:
ATG CCA ATA CCA AAT AAT CCA GGA GCT GGT GAA AAT GCC TTT
GAT CCC GTT TTC GTA AAG GAT GAC GAT GGT TAT GAC CTT GAT
TCT TTT ATG ATC CCT GCA CAT TAT AAA AAA TAT CTT ACC AAG
GTC TTA GTT CCA AAT GGT GTC ATA AAA AAC CGT ATT GAG AAA
TTG GCT TAT GAT ATT AAA AAG GTG TAC AAC AAT GAA GAG TTT
CAT ATT CTT TGT TTG TTG AAA GGT TCT CGT GTT TTT TTC ACT
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Last modified: November 3, 2007