Appeal No. 94-1573 Paper No. 24
Application No. 07/552,744 Page 13
GCT CTC TTA AAG CAT TTA AGT AGA ATA CAT AAT TAT AGT GCC
GTT GAG ACG TCC AAA CCA TTA TTT GGA GAA CAC TAC GTA CGT
GTG AAA TCC TAT TGT AAT GAC CAA TCA ACA GGT ACA TTA GAA
ATT GTA AGT GAA GAT TTA TCT TGT TTA AAA GGA AAA CAT GTA
TTA ATT GTT GAA GAT ATT ATT GAT ACT GGT AAA ACA TTA GTA
AAG TTT TGT GAA TAC TTA AAG AAA TTT GAA ATA AAA ACC GTT
GCC ATC GCT TGT CTT TTT ATT AAA AGA ACA CCT TTG TGG AAT
GGT TTT AAA GCT GAT TTC GTT GGA TTC TCA ATT CCT GAT CAC
TTT GTT GTT GGT TAT AGT TTA GAC TAT AAT GAA ATT TTC AGA
GAT CTT GAC CAT TGT TGT TTG GTT AAT GAT GAG GGA AAA AAG
AAA TAT AAA GCA ACT TCA TTA TAA.
5. An isolated and purified protein which is Plasmodium
falciparum HGPRT enzyme.
6. An expression vector comprising a DNA sequence
encoding for an enzyme selected from the group consisting of
(1) P. falciparum HGPRT enzyme; and (2) a HGPRT active mutant
of P. falciparum HGPRT enzyme or a fragment thereof having
substantially the same activity as the enzyme wherein an amino
acid residue has been inserted, substituted or deleted in or
from the amino acid sequence of the enzyme or its fragment.
7. A purified protein isolated from a recombinant
organism transformed with a vector that codes for the
expression of Plasmodium falciparum HGPRT said protein having
substantially the same amino acid sequence and substantially
the same HGPRT activity as the protein according to Claim 1.
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